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Validated spectrofluorometric method for determination of gemfibrozil in self nanoemulsifying drug delivery systems (SNEDDS)
Sierra Villar, Ana María; Calpena Campmany, Ana Cristina; Halbaut, Lyda; Aróztegui Trenchs, Montserrat; Clares Naveros, Beatriz
Universitat de Barcelona
A spectrofluorometric method has been developed and validated for the determination of gemfibrozil. The method is based on the excitation and emission capacities of gemfibrozil with excitation and emission wavelengths of 276 and 304 nm respectively. This method allows de determination of the drug in a self-nanoemulsifying drug delivery system (SNEDDS) for improve its intestinal absorption. Results obtained showed linear relationships with good correlation coefficients (r(2)>0.999) and low limits of detection and quantification (LOD of 0.075 μg mL(-1) and LOQ of 0.226 μg mL(-1)) in the range of 0.2-5 μg mL(-1), equally this method showed a good robustness and stability. Thus the amounts of gemfibrozil released from SNEDDS contained in gastro resistant hard gelatine capsules were analysed, and release studies could be performed satisfactorily.
Sistemes d'administració de medicaments
Emulsions (Farmàcia)
Nanopartícules
Solucions (Farmàcia)
Medicaments cardiovasculars
Espectroscòpia de fluorescència
Drug delivery devices
Emulsions (Pharmacy)
Nanoparticles
Solutions (Pharmacy)
Cardiovascular agents
Fluorescence spectroscopy
(c) Elsevier B.V., 2013
Artículo
info:eu-repo/semantics/acceptedVersion
Elsevier B.V.
         

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