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Título:	Poly(beta,L-malic acid)Doxorubicin ionic complex: A pH-dependent delivery system.
Autor/a:	Lanz Landazuri, Alberto; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; García Álvarez, Montserrat; Muñoz Guerra, Sebastián
Otros autores:	Universitat Politècnica de Catalunya. Departament d'Enginyeria Química; Universitat Politècnica de Catalunya. POL - Polímers
Abstract:	Poly(ß,L-malic acid) (PMLA) was made to interact with the cationic anticancer drug Doxorubicin (DOX) in aqueous solution to form ionic complexes with different compositions and an efficiency near to 100%. The PMLA/DOX complexes were characterized by spectroscopy, thermal analysis, and scanning electron microscopy. According to their composition, the PMLA/DOX complexes spontaneously self-assembled into spherical micro or nanoparticles with negative surface charge. Hydrolytic degradation of PMLA/DOX complexes took place by cleavage of the main chain ester bond and simultaneous release of the drug. In vitro drug release studies revealed that DOX delivery from the complexes was favored by acidic pH and high ionic strength
Abstract:	Peer Reviewed
Abstract:	Postprint (published version)
Fecha de creación:	26-07-2014
Materia(s):	-Àrees temàtiques de la UPC::Enginyeria química -Biopolymers -Drug development -Poly(malic acid) -Ionic complexes -Doxorubicin complex -pH-dependent -Drug-delivery particle -Biopolímers -Medicaments -- Desenvolupament
Derechos:	Restricted access - publisher's policy
Tipo de documento:	Artículo
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