Título:
|
Preparation of penta-azole containing cyclopeptides: challenges in macrocyclization
|
Autor/a:
|
Hernández Romero, Delia; Riego, Estela; Francesch, Andrés; Cuevas, Carmen; Albericio Palomera, Fernando; Álvarez Domingo, Mercedes
|
Otros autores:
|
Universitat de Barcelona |
Abstract:
|
Herein is described the synthesis of several analogs of the natural product IB-01211 from concatenated azoles, via a biomimetic pathway based on cyclization-oxidation of serine containing peptides combined with the Hantzsch synthesis. The macrocyclization of rigid peptide compounds 1 and 2 to give IB-01211 and its epimer 12b was explored, and the results are compared here to those previously obtained for the macrocyclization of more flexible structures in the syntheses of YM-216391, telomestatin, and IB-01211. Lastly, the preliminary results of anti-tumor activity screening of the synthesized analogs are discussed. |
Materia(s):
|
-Productes naturals -Pèptids -Síntesi orgànica -Compostos heterocíclics -Natural products -Peptides -Organic synthesis -Heterocyclic compounds |
Derechos:
|
(c) Elsevier B.V., 2007
|
Tipo de documento:
|
Artículo Artículo - Versión aceptada |
Editor:
|
Elsevier B.V.
|
Compartir:
|
|