Use this identifier to quote or link this document: http://hdl.handle.net/2072/231924

The Protein quality control system manages plant defence compound synthesis
Pollier, J.; Moses, T.; González-Guzmán, M.; De Geyter, N.; Lippens, S.; Bossche, R.V.; Marhavý, P.; Kremer, A.; Morreel, K.; Guérin, C.J.; Tava, A.; Oleszek, W.; Thevelein, J.M.; Campos Martínez, Narciso; Goormachtig, S.; Goossens, A.
Jasmonates are ubiquitous oxylipin-derived phytohormones that are essential in the regulation of many development, growth and defence processes. Across the plant kingdom, jasmonates act as elicitors of the production of bioactive secondarymetabolites that serve in defence against attackers. Knowledge of the conserved jasmonate perception and early signalling machineries is increasing, but the downstream mechanisms that regulate defence metabolism remain largely unknown. Herewe showthat, in the legumeMedicago truncatula, jasmonate recruits the endoplasmic-reticulum-associated degradation (ERAD)quality control system tomanagethe production of triterpene saponins, widespread bioactive compounds that share a biogenic origin with sterols. An ERAD-type RING membraneanchor E3 ubiquitin ligase is co-expressed with saponin synthesis enzymes to control the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the rate-limiting enzyme in the supply of the ubiquitous terpene precursor isopentenyl diphosphate. Thus, unrestrained bioactive saponin accumulationis prevented and plant development and integrity secured. This control apparatus is equivalent to the ERAD system that regulates sterol synthesis in yeasts and mammals but that uses distinct E3 ubiquitin ligases, of the HMGR degradation 1 (HRD1) type, to direct destruction of HMGR. Hence, the general principles for the management of sterol and triterpene saponin biosynthesis are conserved across eukaryotes but can be controlled by divergent regulatory cues.
2014-06-06
Metabolisme de les plantes
Metabolisme secundari
Biologia molecular vegetal
Genètica vegetal
Plant metabolism
Secondary metabolism
Plant molecular biology
Plant genetics
(c) Nature Publishing Group, 2013
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info:eu-repo/semantics/acceptedVersion
Nature Publishing Group
         

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Pollier, J.; Moses, T.; González-Guzmán, M.; De Geyter, N.; Lippens, S.; Bossche, R.V.; Marhavý, P.; Kremer, A.; Morreel, K.; Guérin, C.J.; Tava, A.; Oleszek, W.; Thevelein, J.M.; Campos Martínez, Narciso; Goormachtig, S.; Goossens, A.
Pollier, J.; Moses, T.; González-Guzmán, M.; De Geyter, N.; Lippens, S.; Bossche, R.V.; Marhavý, P.; Kremer, A.; Morreel, K.; Guérin, C.J.; Tava, A.; Oleszek, W.; Thevelein, J.M.; Campos Martínez, Narciso; Goormachtig, S.; Goossens, A.
Leivar Rico, Pablo; Antolín Llovera, Meritxell; Ferrero Torrero, Sergio; Closa Calvo, Marta; Arró i Plans, Montserrat; Ferrer i Prats, Albert; Boronat i Margosa, Albert; Campos Martínez, Narciso
Antolín Llovera, Meritxell; Leivar Rico, Pablo; Arró i Plans, Montserrat; Ferrer i Prats, Albert; Boronat i Margosa, Albert; Campos Martínez, Narciso
Pollier, Jacob; Moses, Tessa; González-Guzmán, Miguel; De Geyter, Nathan; Lippens, Saskia; Bossche, Robin Vanden; Marhavý, Peter; Kremer, Anna; Morreel, Kris; Guérin, Christopher J.; Tava, Aldo; Oleszek, Wieslaw; Thevelein, Johan M.; Campos Martínez, Narciso; Goormachtig, Sofie; Goossens, Alain
 

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