Nowadays, one of the main research areas in cemented carbides is focused on the replacement of cobalt as a binder for more economical materials with similar or improved properties. Nickel is one of the materials most commonly used to replace cobalt, especially in applications involving corrosion. However, knowledge on mechanical properties, and particularly on fatigue response, of nickel based cemented carbides is relatively scarce. In this study, fracture and fatigue behavior of a nickel-base (11%wt) hardmetal grade with fine-grained tungsten carbide is assessed. With this purpose, fatigue crack growth (FCG) resistance and fatigue limit are determined. The study has been complemented with a fractographic inspection for each testing condition. An analysis of the results from a fatigue mechanics perspective, considering the correlation existing between fracture toughness and flexural strength for the studied material, permits to validate FCG threshold as the effective fracture toughness under cyclic loading.