Understanding disaster risk due to hazard events, such as earthquakes, creates powerful incentives for countries to develop planning options and tools to reduce potential damages. The results of the seismic risk assessment of the city of Barcelona using CAPRA (Comprehensive Approach for Probabilistic Risk Assessment) presented in this paper involve the evaluation of probabilistic losses of the exposed elements using probabilistic metrics, such as the exceedance probability curve, the expected annual loss and the probable maximum loss, which are useful for multi-hazard/risk analyses. The outcomes obtained with technoscientific methodologies like CAPRA are oriented to facilitate decision-making. Using CAPRA, it is possible to design risk transfer instruments; evaluation of probabilistic cost-benefit ratio, to consider the net benefits of risk mitigation strategies; land use planning, loss scenarios for emergency response, early warning, on-line loss assessment mechanisms and holistic evaluation of disaster risk based on indicators. These applications facilitate the integrated risk management by the different stakeholders involved in risk reduction decisionmaking.