To access the full text documents, please follow this link: http://hdl.handle.net/2445/52693

Persistent Systemic Inflamation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype
Agustí García-Navarro, Àlvar; Edwards, Lisa D.; Rennard, Stephen I.; MacNee, William; Tal-Singer, Ruth; Miller, Bruce E.; Vestbo, Jørgen; Lomas, David A.; Calverley, Peter M.; Wouters, Emiel; Crim, Courtney; Yates, Julie C.; Silverman, Edwin K.; Coxson, Harvey O.; Bakke, Per; Mayer, Ruth J.; Celli, Bartolome R.
Universitat de Barcelona
BACKGROUND: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. To explore if the persistence of systemic inflammation is associated with poor clinical outcomes in COPD we assessed patients recruited to the well-characterized ECLIPSE cohort (NCT00292552). METHODS AND FINDINGS: Six inflammatory biomarkers in peripheral blood (white blood cells (WBC) count and CRP, IL-6, IL-8, fibrinogen and TNF-α levels) were quantified in 1,755 COPD patients, 297 smokers with normal spirometry and 202 non-smoker controls that were followed-up for three years. We found that, at baseline, 30% of COPD patients did not show evidence of systemic inflammation whereas 16% had persistent systemic inflammation. Even though pulmonary abnormalities were similar in these two groups, persistently inflamed patients during follow-up had significantly increased all-cause mortality (13% vs. 2%, p<0.001) and exacerbation frequency (1.5 (1.5) vs. 0.9 (1.1) per year, p<0.001) compared to non-inflamed ones. As a descriptive study our results show associations but do not prove causality. Besides this, the inflammatory response is complex and we studied only a limited panel of biomarkers, albeit they are those investigated by the majority of previous studies and are often and easily measured in clinical practice. CONCLUSIONS: Overall, these results identify a novel systemic inflammatory COPD phenotype that may be the target of specific research and treatment.
Malalties de l'aparell respiratori
Malalties pulmonars obstructives cròniques
Assaigs clínics
Respiratory diseases
Chronic obstructive pulmonary diseases
Clinical trials
cc-by (c) Agustí García-Navarro, Àlvar et al., 2012
http://creativecommons.org/licenses/by/3.0/es
Article
info:eu-repo/semantics/publishedVersion
Public Library of Science (PLoS)
         

Show full item record

Related documents

Other documents of the same author

Vestbo, Jørgen; Edwards, Lisa D.; Scanlon, Paul D.; Yates, Julie C.; Agustí García-Navarro, Àlvar; Bakke, Per; Calverley, Peter M.; Celli, Bartolome R.; Coxson, Harvey O.; Crim, Courtney; Lomas, David A.; MacNee, William; Miller, Bruce E.; Silverman, Edwin K.; Tal-Singer, Ruth; Wouters, Emiel; Rennard, Stephen I.
Agustí García-Navarro, Àlvar; Calverley, Peter M.; Celli, Bartolome R.; Coxson, Harvey O.; Edwards, Lisa D.; Lomas, David A.; MacNee, William; Miller, Bruce E.; Rennard, Stephen I.; Silverman, Edwin K.; Tal-Singer, Ruth; Wouters, Emiel; Yates, Julie C.; Vestbo, Jørgen
Wilke, Sarah; Jones, Paul W.; Müllerova, H.; Vestbo, Jørgen; Tal-Singer, Ruth; Franssen, Frits M.E.; Agustí García-Navarro, Àlvar; Bakke, Per; Calverley, Peter M.; Coxson, Harvey O.; Crim, Courtney; Edwards, Lisa D.; Lomas, David A.; MacNee, William; Rennard, Stephen I.; Yates, Julie C.; Wouters, Emiel; Spruit, Martijn A.
Hurst, John R.; Vestbo, Jørgen; Anzueto, Antonio; Locantore, Nicholas; Müllerova, Hana; Tal-Singer, Ruth; Miller, Bruce E.; Lomas, David A.; Agustí García-Navarro, Àlvar; MacNee, William; Calverley, Peter M.; Rennard, Stephen I.; Wouters, Emiel; Wedzicha, Jadwiga A.
Menche, Jörg; Sharma, Amitabh; Cho, Michael H.; Mayer, Ruth J.; Rennard, Stephen I.; Celli, Bartolome R.; Miller, Bruce E.; Locantore, Nicholas; Tal-Singer, Ruth; Ghosh, Soumitra; Larminie, Chris; Bradley, Glyn; Riley, John H.; Agustí García-Navarro, Àlvar; Silverman, Edwin K.; Barabási, Albert László
 

Coordination

 

Supporters