Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat)

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dc.contributor	Universitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.contributor	Universitat Politècnica de Catalunya. ENGMOL - Enginyeria Molecular
dc.contributor.author	Paoletti, Iole
dc.contributor.author	De Gregorio, Vicenza
dc.contributor.author	Baroni, Adone
dc.contributor.author	Tufano, Maria Antonieta
dc.contributor.author	Donnarumma, Giovanna
dc.contributor.author	Pérez González, Juan Jesús
dc.date	2013-12-02
dc.identifier.citation	Paoletti, I. [et al.]. Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat). "Inflammation", 02 Desembre 2013, vol. 36, núm. 6, p. 1316-1326.
dc.identifier.citation	0360-3997
dc.identifier.citation	10.1007/s10753-013-9670-7
dc.identifier.uri	http://hdl.handle.net/2117/21281
dc.language.iso	eng
dc.relation	http://link.springer.com/article/10.1007%2Fs10753-013-9670-7
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Enginyeria química
dc.subject	Peptides
dc.subject	Psoriasis
dc.subject	peptide T
dc.subject	amygdalin analogues
dc.subject	NHEK cells
dc.subject	psoriasis
dc.subject	Pèptids
dc.subject	Psoriasi
dc.title	Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat)
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	Peptide T (PT), an octapeptide fragment located in the V2 region of the HIV-1 gp120- coating protein, appears to be bene fi cial in the treatment of psoriasis. Our previous investigations suggest that keratinocytes play a key role in conditioning the therapeutic effects of PT in psoriasis. The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN- γ and TNF- α -NHEK activated cells. Moreover, we analysed the interference of PT and its analogues through STAT-3 activation. Our results show that the analogues tested exhibit the bene fi cial biol- ogical effects of PT, suggesting the primary role of keratinocytes upon which PT and the peptido- mimetics act directly, by reducing proin fl ammatory responses. Its reduction appears to be important for therapeutic approach in psoriasis pathogenesis
dc.description.abstract	Peer Reviewed

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