Fmoc-2-Mercaptobenzothiazole (MBT), for the Introduction of the Fmoc Moiety Free of Side-Reactions

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dc.contributor	Universitat de Barcelona
dc.contributor.author	Isidro Llobet, Albert
dc.contributor.author	Just Baringo, Xavier
dc.contributor.author	Ewenson, Ariel
dc.contributor.author	Álvarez Domingo, Mercedes
dc.contributor.author	Albericio Palomera, Fernando
dc.date	2007
dc.identifier.citation	0006-3525
dc.identifier.uri	http://hdl.handle.net/2445/48634
dc.description.abstract	A double side-reaction, consisting in the formation of Fmoc--Ala-OH and Fmoc--Ala-AA-OH, during the preparation of Fmoc protected amino acids (Fmoc-AA-OH) with Fmoc-OSu is discussed. Furthermore, the new Fmoc-2-MBT reagent is proposed for avoiding these side-reactions as well as the formation of the Fmoc-dipeptides (Fmoc-AA-AA-OH) and even tripeptides, which is another important side-reaction when chloroformates such as Fmoc-Cl is used for the protection of the -amino function of the amino acids.
dc.format	5 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Wiley
dc.relation	Biopolymers, 2007, vol. 88, num. 5, p. 733-737
dc.rights	(c) Wiley, 2007
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Reaccions químiques
dc.subject	Síntesi de pèptids
dc.subject	Chemical reactions
dc.subject	Peptide synthesis
dc.title	Fmoc-2-Mercaptobenzothiazole (MBT), for the Introduction of the Fmoc Moiety Free of Side-Reactions
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/submittedVersion