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Títol:
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A multi-method approach towards understanding the pathophysiology of aortic dissections – the complementary role of in-silico, in-vitro and in-vivo information
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Autor/a:
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Rudenick, Paula; Bordoné, Maurizio; Bijnens, Bart; Soudah Prieto, Eduardo; Oñate Ibáñez de Navarra, Eugenio; Garcia Dorado, Antonio David; Evangelista, A.
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Altres autors:
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Universitat Politècnica de Catalunya. Departament de Resistència de Materials i Estructures a l'Enginyeria; Universitat Politècnica de Catalunya. (MC)2 - Grup de Mecànica Computacional en Medis Continus |
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Abstract:
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Management and follow-up of chronic aortic dissections continues to be a clinical challenge due to progressive aortic dilatation. To predict dilatation, guidelines suggest follow-up of the aortic diameter. However, dilatation is triggered by haemodynamic parameters (pressure and wall shear stresses (WSS)), and geometry of false (FL) and true lumen (TL). We aimed at a better understanding of TL and FL haemodynamics by performing in-silico (CFD) and in-vitro studies on an idealized dissected aorta and compared this to a typical patient. We observed an increase in diastolic pressure and wall stress in the FL and the presence of diastolic retrograde flow. The inflow jet increased WSS at the proximal FL while a large variability in WSS was induced distally, all being risk factors for wall weakening. In-silico, in-vitro and in-vivo findings were very similar and complementary, showing that their combination can help in a more integrated and extensive assessment of aortic dissections, improving understanding of the haemodynamic conditions and related clinical evolution. |
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Abstract:
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Peer Reviewed |
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Matèries:
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-Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Aplicacions informàtiques a la física i l‘enginyeria
-Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
-Computational fluid dynamics
-Dissecting aortic aneurysms
-Aortic diseases -- Surgery
-Aortic dissection
-Computational Fluid Dynamics
-In-vitro phantoms
-Aortic diseases
-Dinàmica de fluids computacional
-Cor -- Cirurgia |
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Drets:
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Tipus de document:
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Article - Versió publicada
Capítol o part de llibre |
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Publicat per:
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Springer
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