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Calcium phosphate cements loaded with basic fibroblast growth factor: Delivery and in vitro cell response
Perez, Roman; Kim, Tae-Hyun; Kim, Meeju; Jang, Jun-Hyeog; Ginebra Molins, Maria Pau; Kim, Hae-Won
Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica; Universitat Politècnica de Catalunya. BIBITE - Biomaterials, Biomecànica i Enginyeria de Teixits
biological responses, especially in terms of cell proliferation. Here, we used basic fibroblast growth factor (bFGF) in an -tricalcium phosphate cement with different initial powder sizes (coarse vs. fine; designated as CPC-C and CPC-F, respectively) and investigated the behavior of bFGF loading and release, as well as the effects on osteoblast responses. bFGF was loaded at 10 g/ml or 25 g/ml onto the set form of two types of CPCs, aiming to allow penetration into the pore structure and adsorption onto the cement crystallites. The CPC formulated with fine powder (CPC-F) had higher specific surface area and smaller-sized pores and retained slightly higher amounts of bFGF within the structure. The bFGF release study performed for 3 weeks showed a sustained-release profile; after an initial rapid release over approximately...
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
calcium phosphate cements
powder size
growth factor delivery
cell proliferation
bone regeneration
Attribution-NonCommercial-NoDerivs 3.0 Spain

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