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Título:
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Osteogenic biphasic calcium sulphate dihydrate/iron-modified alpha-tricalcium phosphate bone cement for spinal applications : in vivo study
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Autor/a:
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Vlad, María Daniela; Sindilar, E.V.; Mariñoso, Maria Lluïsa; Poeata, I.; Torres Cámara, Ricardo; López López, José; Barraco Serra, Marc; Fernández Aguado, Enrique
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Otros autores:
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Universitat Politècnica de Catalunya. Departament de Mecànica de Fluids; Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear; Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica; Universitat Politècnica de Catalunya. GRICCA - Grup Interdepartamental per a la Col.laboració Científica Aplicada |
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Abstract:
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Premi del "National University Research Council" del Ministeri d'Educació i Recerca de Romania, a autors romanesos per l'impacte de la seva recerca. |
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Abstract:
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In this study, the biocompatibility and the osteogenic features of a new iron-modified α-tricalcium phosphate (IM/α-TCP) and calcium sulphate dihydrate (CSD) biphasic cement (IM/α-TCP/CSD-BC) have been investigated in terms of the in vivo cement resorption, bone tissue formation and host tissue response on sheep animal model. Histological evaluation performed on undecalcified cement–bone specimens assessed the in vivo behaviour. It has been shown that the new IM/α-TCP/CSD-BC has the ability to produce firm bone binding in vivo (i.e. bioactivity). Qualitative histology proved cement biocompatibility, osteoconduction and favourable resorption, mainly through a macrophage-mediated mechanism. The results showed that the new cements have biocompatible and osteogenic features of interest as possible cancellous bone replacement biomaterial for minimally invasive spinal surgery applications. |
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Abstract:
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Peer Reviewed |
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Abstract:
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Award-winning |
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Materia(s):
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-Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
-Bone cements
-Vertebroplasty
-Calcium phosphate cement
-Ciments ossis
-Fosfat de calci
-Vèrtebres -- Cirurgia |
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Derechos:
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Tipo de documento:
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Artículo - Versión publicada
Artículo |
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