To access the full text documents, please follow this link:

Diphenyl urea derivatives as inhibitors of transketolase: a structure-based virtual screening.
Obiol Pardo, Cristian; Alcarráz Vizán, Gemma; Cascante i Serratosa, Marta; Rubio Martínez, Jaime
Universitat de Barcelona
Transketolase is an enzyme involved in a critical step of the non-oxidative branch of the pentose phosphate pathway whose inhibition could lead to new anticancer drugs. Here, we report new human transketolase inhibitors, based on the phenyl urea scaffold, found by applying structure-based virtual screening. These inhibitors are designed to cover a hot spot in the dimerization interface of the homodimer of the enzyme, providing for the first time compounds with a suggested novel binding mode not based on mimicking the thiamine pyrophosphate cofactor.
Inhibidors enzimàtics
Enzyme inhibitors
cc-by (c) Obiol Pardo, C. et al., 2012
Public Library of Science (PLoS)

Show full item record

Related documents

Other documents of the same author

Zanuy Porquet, Miriam; Ramos Montoya, Antonio Francisco; Villacañas, Oscar; Canela, Nuria; Miranda, Anibal; Aguilar Fadó, Esther; Agell i Jané, Neus; Bachs Valldeneu, Oriol; Rubio Martínez, Jaime; Pujol Dilmé, M. Dolors; Lee, Paul Wai Nang; Marín Martínez, Silvia; Cascante i Serratosa, Marta
Kaczor, Agnieszka A.; Guixà González, Ramon, 1978-; Carrió, Pau; Obiol Pardo, Cristian; Pastor Maeso, Manuel; Selent, Jana
Pérez González, Juan Jesús; Tomás Belenguer, María Santos; Rubio Martínez, Jaime
Rubio Martínez, Jaime; Tomás Belenguer, María Santos; Pérez González, Juan Jesús
Gómez Gutierrez, Patricia; Rubio Martínez, Jaime; Pérez González, Juan Jesús