Title:
|
Respiratory chain dysfunction associated with multiple mitochondrial DNA deletions in antiretroviral therapy-related lipodystrophy.
|
Author:
|
Miró, Òscar; Gómez, Montserrat; Pedrol, Enric; Cardellach, Francesc; Nunes Martínez, Virginia; Casademont i Pou, Jordi
|
Other authors:
|
Universitat de Barcelona |
Abstract:
|
Highly-active antiretroviral therapy (HAART) can induce a characteristic lipodystrophy syndrome characterized by peripheral fat wasting and central adiposity, usually associated with hyperlipidaemia and insulin resistance [1,2]. Indirect data have led some authors to propose that mitochondrial dysfunction could play a role in this syndrome [3,4].To date, as recently outlined by Kakuda et al. [5] in this journal, HIV-infected patients developing lipodystrophy have not been studied for mitochondrial changes or respiratory chain capacity... |
Publication date:
|
2013-05-03 |
Subject(s):
|
-Antiretrovirals -Infeccions per VIH -Antiretroviral agents -HIV infections |
Rights:
|
(c) Lippincott Williams & Wilkins, 2000
|
Document type:
|
Article Article - Accepted version |
Published by:
|
Lippincott Williams & Wilkins
|
Share:
|
|