Título:
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Search of phenotype-related candidate genes using Gene Ontology-based semantic similarity and protein interaction information: application to Brugada syndrome
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Autor/a:
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Massanet Vila, Raimon; Gallardo Chacón, Joan Josep; Caminal Magrans, Pere; Perera Lluna, Alexandre
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Otros autores:
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Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial; Universitat Politècnica de Catalunya. SISBIO - Senyals i Sistemes Biomèdics |
Abstract:
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This work presents a methodology for finding
phenotype candidate genes starting from a set of known related genes. This is accomplished by automatically mining
and organizing the available scientific literature using Gene Ontology-based semantic similarity. As a case study, Brugada
syndrome related genes have been used as input in order to obtain a list of other possible candidate genes related with this disease. Brugada anomaly produces a typical alteration in the Electrocardiogram and carriers of the disease show an increased probability of sudden death. Results show a set of semantically coherent proteins that are shown to be related with synaptic transmission and muscle contraction physiological processes. |
Abstract:
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Peer Reviewed |
Materia(s):
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-Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica -Brugada syndrome -Ontologies (artificial intelligence) -Electrocardiography -Heart--Diseases -- Genetic aspects -Síndrome de Brugada -Malalties coronàries |
Derechos:
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Tipo de documento:
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Artículo - Versión publicada Objeto de conferencia |
Editor:
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IEEE Press. Institute of Electrical and Electronics Engineers
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Compartir:
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