This paper deals with a comparative analysis of two different packaging and transport scenarios, which exemplifies the implications of choosing between single-use and reusable packaging. In particular, transport of a batch of chemicals by means of disposable fibre drums vs. reusable steel drums is investigated from a life cycle perspective, and the associated environmental impact in terms of Global Warming Potential, Acidification Potential, Gross Energy Requirement and solid waste generation is assessed. Results prove beyond reasonable doubt that, even in the case of durable packaging containers requiring the use of comparatively energy-intensive materials for their production, the reuse scenario is characterized by lower environmental impact indicators across the board, and as such is the most advisable and environmentally sound option