MicroRNA expression profiling in classic Hodgkin lymphoma

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dc.contributor	Universitat Politècnica de Catalunya. Departament de Llenguatges i Sistemes Informàtics
dc.contributor	Universitat Politècnica de Catalunya. ALBCOM - Algorismia, Bioinformàtica, Complexitat i Mètodes Formals
dc.contributor.author	Monzo, Mariano
dc.contributor.author	Montserrat, Emili
dc.contributor.author	Artells, Rosa
dc.contributor.author	López-Guillermo, Armando
dc.contributor.author	Navarro, Alfons
dc.contributor.author	Gaya, Anna
dc.contributor.author	Martínez Velasco, Antonio Benito
dc.contributor.author	Urbano-Ispiuza, Álvaro
dc.contributor.author	Pons, Aina
dc.contributor.author	Balagué, Olga
dc.contributor.author	Gel Moreno, Bernat
dc.contributor.author	Abrisqueta, Pau
dc.date	2007-12-18
dc.identifier.citation	Navarro, A. [et al.]. MicroRNA expression profiling in classic Hodgkin lymphoma. "Blood", 18 Desembre 2007.
dc.identifier.citation	0006-4971
dc.identifier.citation	10.1182/blood-2007-06-096784
dc.identifier.uri	http://hdl.handle.net/2117/6670
dc.language.iso	eng
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Medicina interna
dc.subject	Hematological oncology
dc.subject	Càncer -- Investigació
dc.title	MicroRNA expression profiling in classic Hodgkin lymphoma
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	MicroRNAs (miRNAs) are negative regulators of gene expression that play an important role in hematopoiesis and tumorigenesis. We analyzed miRNA expression in classic Hodgkin lymphoma (cHL) and the influence of Epstein-Barr virus (EBV) infection on the miRNA expression profiles. The expression of 157 miRNAs in lymph nodes from 49 cHL patients and 10 reactive lymph nodes (RLNs) was analyzed by real-time polymerase chain reaction (PCR). Hierarchic clustering revealed 3 well-defined groups: nodular sclerosis cHL, mixed cellularity cHL, and RLNs. A distinctive signature of 25 miRNAs differentiated cHL from RLNs, and 36 miRNAs were differentially expressed in the nodular sclerosis and mixed cellularity subtypes. These results were validated in a set of 30 cHLs and 5 RLNs, and in 3 cHL cell lines. miR-96, miR-128a, and miR- 128b were selectively down-regulated in cHL with EBV. Our findings suggest that miRNAs play an important role in the biology of cHL and may be useful in developing therapies targeting miRNAs.
dc.description.abstract	Peer Reviewed

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