Title:
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Biological convergence of cancer signatures
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Author:
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Pujana, Miguel Angel; Moreno Fernández, Mario Victor; Capellá Frau, Gabriel José; Comellas Padró, Francesc de Paula; Sanjosé, Silvia de; Urruticoechea, Ander; Solé, Xavier; Bonifaci, Núria; López Bigas, Núria; Berenguer, Antoni; Hernández, Pilar; Reina, Oscar; Maxwell, Christopher A.; Aguilar, Helena
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Other authors:
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Universitat Politècnica de Catalunya. Departament de Matemàtica Aplicada IV; Universitat Politècnica de Catalunya. COMBGRAPH - Combinatòria, Teoria de Grafs i Aplicacions |
Abstract:
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Gene expression profiling has identified cancer prognostic and predictive signatures with superior performance to
conventional histopathological or clinical parameters. Consequently, signatures are being incorporated into clinical practice
and will soon influence everyday decisions in oncology. However, the slight overlap in the gene identity between signatures
for the same cancer type or condition raises questions about their biological and clinical implications. To clarify these issues,
better understanding of the molecular properties and possible interactions underlying apparently dissimilar signatures is
needed. Here, we evaluated whether the signatures of 24 independent studies are related at the genome, transcriptome or
proteome levels. Significant associations were consistently observed across these molecular layers, which suggest the
existence of a common cancer cell phenotype. Convergence on cell proliferation and death supports the pivotal
involvement of these processes in prognosis, metastasis and treatment response. In addition, functional and molecular
associations were identified with the immune response in different cancer types and conditions that complement the
contribution of cell proliferation and death. Examination of additional, independent, cancer datasets corroborated our
observations. This study proposes a comprehensive strategy for interpreting cancer signatures that reveals common design
principles and systems-level properties. |
Abstract:
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Peer Reviewed |
Subject(s):
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-Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències -Biomathematics -Biomatemàtica -Classificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general |
Rights:
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Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Document type:
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Article - Published version Article |
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