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Title:
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HIV-1 immune activation induces siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells
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Author:
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Pino, Maria; Erkizia, Itziar; Benet, Susana; Erikson, Elina; Fernández Figueras, María Teresa; Guerrero, Dolores; Dalmau, Judith; Ouchi, Dan; Rausell, Antonio; Ciuffi, Angela; Keppler, Oliver T.; Telenti, Amalio; Kräusslich, H.G.; Martinez Picado, Francisco Javier; Izquierdo Useros, Nuria
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Other authors:
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Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades |
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Notes:
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Background: Myeloid cells are key players in the recognition and response of the host against invading viruses.
Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a
mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. The receptor Siglec-1
(CD169) potently enhances HIV-1 trans-infection and is regulated by immune activating signals present throughout
the course of HIV-1 infection, such as interferon α (IFNα).
Results: Here we show that IFNα-activated dendritic cells, monocytes and macrophages have an enhanced ability
to capture and trans-infect HIV-1 via Siglec-1 recognition of viral membrane gangliosides. Monocytes from untreated
HIV-1-infected individuals trans-infect HIV-1 via Siglec-1, but this capacity diminishes after effective antiretroviral
treatment. Furthermore, Siglec-1 is expressed on myeloid cells residing in lymphoid tissues, where it can mediate
viral trans-infection.
Conclusions: Siglec-1 on myeloid cells could fuel novel CD4+ T-cell infections and contribute to HIV-1 dissemination
in vivo. |
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Subject(s):
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-Sida -- Tractament
-VIH (Virus) |
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Rights:
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Aquest document està subjecte a aquesta llicència Creative Commons
http://creativecommons.org/licenses/by/3.0/es/
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Document type:
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Article
info:eu-repo/publishedVersion |
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Published by:
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BioMed Central
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