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Title:
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The relative importance of transcription rate, cryptic transcription and mRNA stability on shaping stress responses in yeast
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Author:
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García-Martínez, José; Ayala, Guillermo; Pelechano, Vicent; Chávez, Sebastián; Herrero Perpiñán, Enrique; Pérez-Ortín, José E.
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Notes:
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It has been recently stated that stress-responding genes in yeast are enriched in cryptic transcripts and that this is the
cause of the differences observed between mRNA amount and RNA polymerase occupancy profiles. Other studies have
shown that such differences are mainly due to modulation of mRNA stabilities. Here we analyze the relationship between
the presence of cryptic transcripts in genes and their stress response profiles. Despite some of the stress-responding
gene groups being indeed enriched in specific classes of cryptic transcripts, we found no statistically significant evidence
that cryptic transcription is responsible for the differences observed between mRNA and transcription rate profiles. |
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Subject(s):
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-TR
-transcription rate
-ChIP |
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Rights:
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(c) Landes Bioscience, 2012
(c) Taylor & Francis, 2012
info:eu-repo/semantics/restrictedAccess |
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Document type:
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article
publishedVersion |
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Published by:
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Taylor & Francis;
Landes Bioscience
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