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Título:
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Vitamin D receptor BsmI polymorphism modulates soy intake and 25-hydroxyvitamin D supplementation benefits in cardiovascular disease risk factors profile
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Autor/a:
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Serrano Casasola, José Carlos Enrique; de Lorenzo, David; Cassanyé, Anna; Martín-Gari, Meritxell; Espinel, Alberto; Delgado, Marco Antonio; Pamplona Gras, Reinald; Portero Otín, Manuel
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Notas:
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Vitamin D receptor polymorphisms may predispose
that not all individuals could have benefits from the
nutritional supplementation of 25-hydroxyvitamin D. Furthermore,
vitamin D-related cardiovascular effects may
also be influenced by soy isoflavones considered endocrine
regulators of cardiovascular homeostasis. To find possible
gene–diet interactions by evaluating individualized lipid
metabolism benefits from an increase in soy and 25-hydroxyvitamin
D intake, 106 healthy individuals, genotyped
for vitamin D receptor (VDR) gene polymorphism
rs1544410 (BsmI) were randomly assigned to either no
intake, to daily 250 mL or 500 mL of a 25-hydroxyvitamin
D supplemented SB for 2 months. The soybean beverage
induced differences in cardiovascular risk factors (lipid
profile, blood pressure, TNFa and MCP-1), as well as
vitamin D metabolites in a dose-gene-dependent relation.
Thus, VDR BsmI polymorphism affected individual
response being the GG genotype the ones that showed
dose-dependent manner responsiveness in the reduction in
total cholesterol, LDL and triglycerides in comparison with
the AA/AG genotype. These differences were associated
with increased plasma levels of 1a,25-dyhydroxyvitamin
D3 in the carriers of the GG genotype. It was concluded
that metabolic response to 25-hydroxyvitamin D and soybean
supplementation is dependent on VDR BsmI GG
genotype due to a higher conversion rate from vitamin D
precursors. |
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Materia(s):
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-Vitamin D receptor
-Vitamin D
-Soy |
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Derechos:
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(c) Springer Verlag, 2013
info:eu-repo/semantics/restrictedAccess |
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Tipo de documento:
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article
publishedVersion |
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Editor:
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Springer Verlag
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Compartir:
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