dc.contributor.author |
Valls i Bautista, Cristina |
dc.contributor.author |
Piñol Felis, Carme |
dc.contributor.author |
Reñé Espinet, Josep Maria |
dc.contributor.author |
Buenestado Garcia, Juan |
dc.contributor.author |
Viñas Salas, Joan |
dc.date |
2015-04-30T17:20:29Z |
dc.date |
2015-04-17 |
dc.date |
2015-04-30T17:20:30Z |
dc.date |
10000-01-01 |
dc.identifier |
0022-4790 |
dc.identifier |
http://hdl.handle.net/10459.1/48172 |
dc.identifier |
https://doi.org/10.1002/jso.23894 |
dc.identifier.uri |
http://hdl.handle.net/10459.1/48172 |
dc.description |
Background: Telomere length (TL) shortened occurs in colorectal carcinogenetic process. Our objective is to determine if it is only a local fact or there are alterations in normal colon cells and in other body cells. Methods: TL of tumoral and normal mucosa and leukocytes of 40 patients operated of colorectal cancer (CRC) and 40 control patients with normal colonoscopy were measured by Southern-blot. Groups were matched by the same localization as tumors, sex, and age. Results: In CRC patients, TRFL (Telomere Repeat Factor Length) leukocytes mean was 8.84 kpb, normal colonic mucosa 7.97 kpb, and tumoral mucosa 7.33 kpb (P<0.001). In the 40 normal control patients, mean TRFL of colonic mucosa was 7.76 kpb, while in blood cells was 7.01 kpb (P<0.001). We observed an inverse correlation between leukocytes TRFL and age (r2=0.17, P=0.008). Mucosa TRFL correlates significantly with patient"s age (r2=0.138, P=0.018). TRFL of controls colonic mucosa correlates with TRFL of their blood cells (r2=0.354, P<0.001). Conclusions: Normal colonic mucosa and leukocytes in CCR patients presents telomere altered in respect to normal patients. Telomere length in normal leukocytes could be an initial marker for colorectal cancer. |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
Wiley Online Library |
dc.relation |
Reproducció del document publicat a: https://doi.org/10.1002/jso.23894 |
dc.relation |
Journal of Surgical Oncology, 2015, vol. 111, num. 7, p. 899-904 |
dc.rights |
(c) Wiley Periodicals, 2015 |
dc.rights |
info:eu-repo/semantics/restrictedAccess |
dc.subject |
telomere behaviour |
dc.subject |
telomere length |
dc.subject |
telomere in blood cells |
dc.subject |
càncer colorectal |
dc.subject |
Telòmer |
dc.subject |
Càncer colorectal |
dc.subject |
Telomere |
dc.subject |
Colorectal cancer |
dc.title |
In colon cancer, normal colon tissue and blood cells have altered telomere lengths |
dc.type |
info:eu-repo/semantics/article |
dc.type |
publishedVersion |