dc.contributor.author |
Herrero Perpiñán, Enrique |
dc.contributor.author |
Torre Ruiz, M. A. de la |
dc.date |
2014-07-25T09:25:29Z |
dc.date |
2014-07-25T09:25:29Z |
dc.date |
2007 |
dc.identifier |
1420-682X (versió paper) |
dc.identifier |
1420-9071 |
dc.identifier |
http://hdl.handle.net/10459.1/47442 |
dc.identifier |
https://doi.org/10.1007/s00018-007-6554-8 |
dc.identifier.uri |
http://hdl.handle.net/10459.1/47442 |
dc.description |
Monothiol glutaredoxins with the CGFS sequence at the active site are widespread among prokaryotes and eukaryotes. Two subclasses exist, those with a single glutaredoxin domain and those with a thioredoxin-like region followed by one or
more glutaredoxin domains. Studies in Saccharomyces cerevisiae have demonstrated the role of the Grx5 protein in the biogenesis of iron-sulphur clusters. Grx5 homologues in other eukaryotes could carry out similar functions. Two S. cerevisiae monothiol glutaredoxins with the thioredoxin-like extension, Grx3 and Grx4, are modulators of the transcriptional activator Aft1, which regulates iron uptake in yeast. The human PICOT protein is a Grx3/Grx4 homologue with the same hybrid primary structure, which regulates protein kinase C activity and may participate in physiological processes such as control of cardiac function. Therefore, monothiol glutaredoxins share a common basic structural motif and biochemical mechanism of action, while participating in a diversity of cellular functions as protein redox regulators. |
dc.language |
eng |
dc.publisher |
Springer |
dc.relation |
Versió preprint del document publicat a https://doi.org/10.1007/s00018-007-6554-8 |
dc.relation |
Cellular and molecular life sciences : CMLS, 2007, vol. 64, núm. 12, p. 1518-1530 |
dc.rights |
(c) Birkhäuser Verlag, 2007 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Glutaredoxin |
dc.subject |
Estrès oxidatiu |
dc.subject |
Llevat de cervesa |
dc.subject |
Estrès oxidatiu |
dc.subject |
Saccharomyces cerevisiae |
dc.title |
Monothiol glutaredoxins: a common domain for multiple functions |
dc.type |
article |
dc.type |
submittedVersion |