dc.contributor.author |
Nàger Grifo, Mireia |
dc.contributor.author |
Bhardwaj, Deepshikha |
dc.contributor.author |
Cantí Nicolás, Carles |
dc.contributor.author |
Medina Hernández, Loreta Mª |
dc.contributor.author |
Nogués Bara, Pere |
dc.contributor.author |
Herreros Danés, Judit |
dc.date |
2013-01-08T09:07:56Z |
dc.date |
2013-01-08T09:07:56Z |
dc.date |
2012 |
dc.identifier |
2090-2107 |
dc.identifier |
http://hdl.handle.net/10459.1/46382 |
dc.identifier |
https://doi.org/10.1155/2012/192362 |
dc.identifier.uri |
http://hdl.handle.net/10459.1/46382 |
dc.description |
Glioblastoma multiforme (GBM) is a commonly occurring brain tumor with a poor prognosis. GBM can develop both “de novo” or evolve from a previous astrocytoma and is characterized by high proliferation and infiltration into the surrounding tissue. Following treatment (surgery, radiotherapy, and chemotherapy), tumors often reappear. Glioma-initiating cells (GICs) have been identified in GBM and are thought to be responsible for tumors initiation, their continued growth, and recurrence.
β-catenin, a component of the cell-cell adhesion complex and of the canonical Wnt pathway, regulates proliferation, adhesion, and migration in different cell types. β-catenin and components of the Wnt canonical pathway are commonly overexpressed in GBM. Here, we review previous work on the role of Wnt/β-catenin signalling in glioma initiation, proliferation, and invasion. Understanding the molecular mechanisms regulating GIC biology and glioma progression may help in identifying novel therapeutic targets for GBM treatment. |
dc.language |
eng |
dc.publisher |
Hindawi Publishing Corporation |
dc.relation |
Reproducció del document publicat a: https://doi.org/10.1155/2012/192362 |
dc.relation |
Chemotherapy Research and Practice, 2012, vol. 2012, ID 192362, p. 1-7 |
dc.rights |
cc-by, (c) Mireia Nager et al., 2012 |
dc.rights |
http://creativecommons.org/licenses/by/3.0/es/deed.ca |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
GBM |
dc.subject |
GBM Recurrence |
dc.subject |
Cervell -- Tumors |
dc.subject |
Sistema nerviós central -- Tumors |
dc.subject |
Càncer |
dc.subject |
Cèl·lules -- Proliferació |
dc.subject |
Neurobiologia |
dc.subject |
Proteïnes -- Anàlisi |
dc.title |
β-catenin signalling in Glioblastoma multiforme and Glioma-initiating cells |
dc.type |
article |
dc.type |
publishedVersion |