https://hdl.handle.net/2072/478778 2026-03-27T05:48:50Z 2026-03-27T05:48:50Z Almodóvar Payá, Carmen Guardiola Ripoll, Maria Giralt López, Maria Oscoz Irurozqui, Maitane Canales Rodríguez, Erick Jorge Madre, Mercè Soler-Vidal, Joan Ramiro, Núria Callado, Luis F. Arias Sampériz, Bárbara Gallego González, Carmen Pomarol-Clotet, Edith Fatjó-Vilas Mestre, Mar https://hdl.handle.net/2445/228489 2026-03-26T11:44:55Z 2026-03-25T08:45:54Z

NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia Almodóvar Payá, Carmen; Guardiola Ripoll, Maria; Giralt López, Maria; Oscoz Irurozqui, Maitane; Canales Rodríguez, Erick Jorge; Madre, Mercè; Soler-Vidal, Joan; Ramiro, Núria; Callado, Luis F.; Arias Sampériz, Bárbara; Gallego González, Carmen; Pomarol-Clotet, Edith; Fatjó-Vilas Mestre, Mar The expression of Neuritin-1 (NRN1), a neurotrophic factor crucial for neurodevelopment and synaptic plasticity, is enhanced by the Brain Derived Neurotrophic Factor (BDNF). Although the receptor of NRN1 remains unclear, it is suggested that NRN1’s activation of the insulin receptor (IR) pathway promotes the transcription of the calcium voltage-gated channel subunit alpha1 C (CACNA1C). These three genes have been independently associated with schizophrenia (SZ) risk, symptomatology, and brain differences. However, research on how they synergistically modulate these phenotypes is scarce. We aimed to study whether the genetic epistasis between these genes affects the risk and clinical presentation of the disorder via its effect on brain structure. First, we tested the epistatic effect of NRN1 and BDNF or CACNA1C on (i) the risk for SZ, (ii) clinical symptoms severity and functionality (onset, PANSS, CGI and GAF), and (iii) brain cortical structure (thickness, surface area and volume measures estimated using FreeSurfer) in a sample of 86 SZ patients and 89 healthy subjects. Second, we explored whether those brain clusters influenced by epistatic effects mediate the clinical profiles. Although we did not find a direct epistatic impact on the risk, our data unveiled significant effects on the disorder’s clinical presentation. Specifically, the NRN1-rs10484320 x BDNF-rs6265 interplay influenced PANSS general psychopathology, and the NRN1-rs4960155 x CACNA1C-rs1006737 interaction affected GAF scores. Moreover, several interactions between NRN1 SNPs and BDNF-rs6265 significantly influenced the surface area and cortical volume of the frontal, parietal, and temporal brain regions within patients. The NRN1-rs10484320 x BDNF-rs6265 epistasis in the left lateral orbitofrontal cortex fully mediated the effect on PANSS general psychopathology. Our study not only adds clinical significance to the well-described molecular relationship between NRN1 and BDNF but also underscores the utility of deconstructing SZ into biologically validated brain-imaging markers to explore their mediation role in the path from genetics to complex clinical manifestation.

2026-03-25T08:45:54Z Trillas Gay, M. Isabel Segarra Braunstein, Guillem Avilés, Manuel, 1955- https://hdl.handle.net/2445/228458 2026-03-25T11:57:20Z 2026-03-24T12:05:52Z

Is Trichoderma ear rot on maize really a new dangerous plant disease? Trillas Gay, M. Isabel; Segarra Braunstein, Guillem; Avilés, Manuel, 1955- N/A

2026-03-24T12:05:52Z Viladrich Canudas, Núria Gori, Andrea Capdevila Lanzaco, Pol Montseny Cuscó, Maria Santín, Andreu Montero‐Serra, Ignasi Pagès-Escolà, Marta Garrabou, Joaquim Linares Prats, Cristina https://hdl.handle.net/2445/228046 2026-03-13T17:24:07Z 2026-03-12T15:03:27Z

Global warming drives phenological shifts and hinders reproductive success in a temperate octocoral Viladrich Canudas, Núria; Gori, Andrea; Capdevila Lanzaco, Pol; Montseny Cuscó, Maria; Santín, Andreu; Montero‐Serra, Ignasi; Pagès-Escolà, Marta; Garrabou, Joaquim; Linares Prats, Cristina Global warming is profoundly reshaping biodiversity. Until now, most research has focused on the impacts of extreme temperature events. However, in many ecosystems, it is becoming increasingly apparent that climate change is accelerating the onset of spring warming conditions. These advanced warming conditions can significantly disrupt critical biological processes such as reproduction, which is key for population persistence. While interest in phenological shifts has increased in recent years, their effects on marine foundation species, such as corals, remain poorly understood. Here, we combined observational and experimental approaches to assess the effects of advanced spring warming conditions driven by climate change on the reproduction of the Mediterranean octocoral Paramuricea clavata, a foundation species. Our findings reveal that a 2°C warming leads to a 2-week advancement in P. clavata spawning, as evidenced by both field observations, and ex-situ experiments. These results underscore the role of advanced spring warming as a significant driver of phenological shifts in coastal marine ecosystems. Furthermore, we show that this phenological shift lead to a reduction in the number of spawning events, as well as decreases in larval biomass, survival rates, and settlement success. These findings highlight the urgent necessity to monitor phenological changes in foundational marine species, as such shifts can undermine the long-term viability of coral populations and contribute to a substantial decline in associated biodiversity. Consequently, the increased vulnerability of species caused by phenological responses driven by seasonal changes may lead to more dramatic consequences of ocean warming than previously anticipated

2026-03-12T15:03:27Z Tichý, Lubomír Axmanová, Irena Dengler, Jürgen Guarino, Riccardo Jansen, Florian Midolo, Gabriele Nobis, Michael P. Van Meerbeek, Koenraad Acic, Svetlana Attorre, Fabio Chytrý, Milan Díte, Daniel Díte, Zuzana Dziuba, Tetiana Fanelli, Giuliano Fernández-Pascual, Eduardo Garbolino, Emmanuel Gavilán, Rosario G. Gégout, Jean-Claude Graf, Ulrich Güler, Behlül Hájek, Michal Hennekens, Stephan M. Jandt, Ute Jasková, Anni Jiménez-Alfaro, Borja Julve, Philippe Kambach, Stephan Karger, Dirk N. Karrer, Gerhard Kavgaci, Ali Knollová, Ilona Kuzemko, Anna Küzmic, Filip Landucci, Flavia Lengyel, Attila Lenoir, Jonathan Marcenò, Corrado Moeslund, Jesper Erenskjold Novák, Pavel Pérez Haase, Aaron Peterka, Tomás Pielech, Remigiusz Pignatti, Alessandro Rasomavicius, Valerijus Bergmeier, Erwin Rusina, Solvita Biurrun, Idoia Saatkamp, Arne Bonari, Gianmaria Urban Silc Bruelheide, Helge Skvorc, Zeljko Campos, Juan Antonio Theurillat, Jean-Paul Carni, Andraz Wohlgemuth, Thomas Chiarucci, Alessandro Cuk, Mirjana Custerevska, Renata Didukh, Yakiv https://hdl.handle.net/2445/228022 2026-03-13T17:23:20Z 2026-03-12T07:25:38Z

Ellenberg-type indicator values for European vascular plant species Tichý, Lubomír; Axmanová, Irena; Dengler, Jürgen; Guarino, Riccardo; Jansen, Florian; Midolo, Gabriele; Nobis, Michael P.; Van Meerbeek, Koenraad; Acic, Svetlana; Attorre, Fabio; Chytrý, Milan; Díte, Daniel; Díte, Zuzana; Dziuba, Tetiana; Fanelli, Giuliano; Fernández-Pascual, Eduardo; Garbolino, Emmanuel; Gavilán, Rosario G.; Gégout, Jean-Claude; Graf, Ulrich; Güler, Behlül; Hájek, Michal; Hennekens, Stephan M.; Jandt, Ute; Jasková, Anni; Jiménez-Alfaro, Borja; Julve, Philippe; Kambach, Stephan; Karger, Dirk N.; Karrer, Gerhard; Kavgaci, Ali; Knollová, Ilona; Kuzemko, Anna; Küzmic, Filip; Landucci, Flavia; Lengyel, Attila; Lenoir, Jonathan; Marcenò, Corrado; Moeslund, Jesper Erenskjold; Novák, Pavel; Pérez Haase, Aaron; Peterka, Tomás; Pielech, Remigiusz; Pignatti, Alessandro; Rasomavicius, Valerijus; Bergmeier, Erwin; Rusina, Solvita; Biurrun, Idoia; Saatkamp, Arne; Bonari, Gianmaria; Urban Silc; Bruelheide, Helge; Skvorc, Zeljko; Campos, Juan Antonio; Theurillat, Jean-Paul; Carni, Andraz; Wohlgemuth, Thomas; Chiarucci, Alessandro; Cuk, Mirjana; Custerevska, Renata; Didukh, Yakiv Aims Ellenberg-type indicator values are expert-based rankings of plant species according to their ecological optima on main environmental gradients. Here we extend the indicator-value system proposed by Heinz Ellenberg and co-authors for Central Europe by incorporating other systems of Ellenberg-type indicator values (i.e., those using scales compatible with Ellenberg values) developed for other European regions. Our aim is to create a harmonized data set of Ellenberg-type indicator values applicable at the European scale. Methods We collected European data sets of indicator values for vascular plants and selected 13 data sets that used the nine-, ten- or twelve-degree scales defined by Ellenberg for light, temperature, moisture, reaction, nutrients and salinity. We compared these values with the original Ellenberg values and used those that showed consistent trends in regression slope and coefficient of determination. We calculated the average value for each combination of species and indicator values from these data sets. Based on species' co-occurrences in European vegetation plots, we also calculated new values for species that were not assigned an indicator value. Results We provide a new data set of Ellenberg-type indicator values for 8908 European vascular plant species (8168 for light, 7400 for temperature, 8030 for moisture, 7282 for reaction, 7193 for nutrients, and 7507 for salinity), of which 398 species have been newly assigned to at least one indicator value. Conclusions The newly introduced indicator values are compatible with the original Ellenberg values. They can be used for large-scale studies of the European flora and vegetation or for gap-filling in regional data sets. The European indicator values and the original and taxonomically harmonized regional data sets of Ellenberg-type indicator values are available in the Supporting Information and the Zenodo repository.

2026-03-12T07:25:38Z