2026-04-17T15:55:58Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/959872025-12-05T14:51:39Zcom_2072_1057col_2072_478917col_2072_478924

Low levels of a urinary biomarker of dietary polyphenol are associated with substantial cognition decline over a three-year period in older adults: the Invecchiare in Chianti (InCHIANTI) Study. Rabassa Bonet, Montserrat Cherubini, Antonio Zamora-Ros, Raul Urpí Sardà, Mireia Bandinelli, Stefania Ferrucci, Luigi Andrés Lacueva, Ma. Cristina Trastorns de la cognició Polifenols Marcadors bioquímics Cognition disorders Polyphenols Biochemical markers Objectives: To investigate the association of total urinary polyphenols (TUP) and total dietary polyphenols (TDP) with cognitive decline in an older population. Design: The Invecchiare in Chianti (InCHIANTI) study, a cohort study with a 3-year of follow-up. Setting: tuscany, italy. Participants: Non-demented adults aged 65 and older (N=652). Measurements: TUP and TDP concentrations were analysed at baseline using the Folin-Ciocalteu assay and a validated food frequency questionnaire, respectively. Cognition was assessed using the Mini-Mental State Examination (MMSE) and Trail Making Test (TMT) at baseline and after three years of follow-up. A substantial cognitive decline was defined as a reduction in the MMSE score of 3 or more points and as an increase of at least 29 seconds on the TMT A and 68 seconds on the TMT B (these thresholds represent the worst 10% of the distribution of decline) or as test discontinued due to multiple mistakes in TMT A and B at follow-up. Results: Higher TUP levels were associated with lower risk of substantial cognitive decline on the MMSE (odds ratio [OR] comparing extreme tertiles = 0.53; 95% confidence interval [CI] = 0.34<br>0.85; P-trend = 0.008) and on the TMT-A (OR = 0.52; 95 % CI = 0.28<br>0.96; P-trend = 0.03), but not on TMT-B in a logistic regression model that adjusted for baseline cognitive score and potential confounding factors. TDP did not affect the developing substantial cognitive decline in both tests. Conclusion: High concentrations of polyphenols, a nutritional biomarker of polyphenol intake, were associated with a lower risk of substantial cognitive decline in the older population studied over a three-year period, suggesting a protective effect against cognitive impairment. 2016-02-29T17:09:37Z 2016-05-31T22:01:24Z 2015-05 2016-02-29T17:09:42Z info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion 0002-8614 https://hdl.handle.net/2445/95987 647358 25919574 eng Versió postprint del document publicat a: http://dx.doi.org/10.1111/jgs.13379 Journal of the American Geriatrics Society, 2015, vol. 63, num. 5, p. 938-946 http://dx.doi.org/10.1111/jgs.13379 (c) The American Geriatrics Society, 2015 info:eu-repo/semantics/openAccess 9 p. application/pdf Wiley Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)