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Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model. Costelli, Paola Carbó Carbó, Neus Tessitore, Luciana Bagby, Gregory J. López-Soriano, Francisco J. Argilés Huguet, Josep Ma. Baccino, Francesco M. Tumors Necrosi Músculs Tumor necrosis factor Skeletal muscle Protein turnover Rats bearing the Yoshida AH-130 ascites hepatoma showed enhanced fractional rates of protein degradation in gastrocnemius muscle, heart, and liver, while fractional synthesis rates were similar to those in non-tumor bearing rats. This hypercatabolic pattern was associated with marked perturbations of the hormonal homeostasis and presence of tumor necrosis factor in the circulation. The daily administration of a goat anti-murine TNF IgG to tumor-bearing rats decreased protein degradation rates in skeletal muscle, heart, and liver as compared with tumor-bearing rats receiving a nonimmune goat IgG. The anti-TNF treatment was also effective in attenuating early perturbations in insulin and corticosterone homeostasis. Although these results suggest that tumor necrosis factor plays a significant role in mediating the changes in protein turnover and hormone levels elicited by tumor growth, the inability of such treatment to prevent a reduction in body weight implies that other mediators or tumor-related events were also involved. 2009-05-14T10:14:17Z 2009-05-14T10:14:17Z 1993 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 0021-9738 https://hdl.handle.net/2445/8263 79740 8254032 eng Reproducció del document publicat a http://dx.doi.org/doi:10.1172/JCI116897 Journal of Clinical Investigation, 1993, vol. 92, núm. 6, p. 2783-2789. (c) The American Society for Clinical Investigation, 1993 info:eu-repo/semantics/openAccess 7 p. application/pdf American Society for Clinical Investigation Articles publicats en revistes (Bioquímica i Biomedicina Molecular)