2026-04-13T02:40:52Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/685702025-11-19T11:04:22Zcom_2072_1057col_2072_478917col_2072_478924

00925njm 22002777a 4500 dc Abbatecola, Angela M. author Cherubini, Antonio author Guralnik, Jack M. author Andrés Lacueva, Ma. Cristina author Ruggiero, Carmelinda author Maggio, Marcello author Bandinelli, Stefania author Paolisso, Giuseppe author Ferrucci, Luigi author 2015-12-22T16:00:37Z 2015-12-22T16:00:37Z 2009-02 2015-12-22T16:00:37Z Due to supporting evidence that dietary patterns may have a significant role in the maintenance of good physical performance with aging, we tested whether plasma fatty acids, saturated fatty acids (SFA), and polyunsaturated (PUFA) fatty acids are cross-sectionally associated with different physical performance and predict changes in physical performance over a 3-year period. Data were from the InCHIANTI study, a population-based study of older Italians. Plasma fatty acids were measured at enrollment (1998-2000), and outcome variables, Summary Physical Performance Battery (SPPB), and time to walk 7 meters (m) were measured at enrollment and after 3 years (2001-2004). At enrollment, 330 participants had significantly impaired lower extremity performance (defined as a SPPB score < or = 9). Adjusting for age, participants with a SPPB score > 9 had higher levels of total PUFA, n-3 PUFA, and n-6 PUFA, while significantly lower levels of SFA than those with a SPPB score < 9. Baseline SPPB scores were also associated with n-3 PUFA (beta = 0.148, p = 0.031), whereas the 7-m walk time was associated with total PUFA (beta = - 0.068, p = 0.008), after adjusting for potential confounders. Of the 884 participants with a SPPB score > 9 at baseline, 114 (12.9%) developed impaired lower extremity performance (SPPB < or = 9). In fully adjusted logistic models, baseline n-3 PUFA levels were inversely related to the risk of developing a decline in SPPB to < or = 9 (odds ratio [OR] = 0.21; 95% confidence interval [CI] = 0.08-0.53), while the n-6/n-3 ratio was associated with a higher risk of SPPB decline to < or = 9 (OR = 5.23; 95% CI = 2.02-13.51). In multivariate regression models, the n-6/n-3 ratio was associated with a longer time to walk 7 m (beta = 0.396, p = 0.037). n-3 PUFA plasma levels, which most likely reflect dietary intake, seem to protect against accelerated decline of physical performance. A higher n-6/n-3 ratio was associated with higher risk of developing poor physical performance and slower walking speed. Envelliment Àcids grassos insaturats Motricitat Condició física Aging Unsaturated fatty acids Motor ability Physical fitness Plasma polyunsaturated fatty acids and age-related physical performance decline