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00925njm 22002777a 4500 dc Metón Teijeiro, Isidoro author Salgado Martín, María del Carmen author Anemaet, Ida Guurtje author González, Juan D. author Fernández González, Felipe Javier author Vázquez Baanante, Ma. Isabel author 2015-10-30T16:20:57Z 2015-10-30T16:20:57Z 2015 Podeu consultar el llibre complet a: http://hdl.handle.net/2445/67430 Alanine aminotransferase (ALT) is a sensitive marker of dietary protein utilisation in fish. Three ALT isoforms (cALT1, cALT2 and mALT) encoded by two genes have been isolated from gilthead sea bream (Sparus aurata). Molecular characterization of ALT isozymes and gene promoters suggest involvement of cALT1 and mALT in postprandial use of dietary amino acids, while cALT2 seems associated to hepatic gluconeogenesis. Inhibition of hepatic cytosolic ALT activity stimulates pyruvate kinase and decreases the renewal rate of alanine in S. aurata. These findings point to ALT as a target to spare protein and improve catabolism of dietary carbohydrates in cultured fish. Transferases Suplements nutritius Orada Aqüicultura Bioquímica Biologia molecular Transferases Dietary supplements Aquaculture Biochemistry Molecular biology Sparus aurata Alanine aminotransferase: A target to improve utilisation of dietary nutrients in aquaculture