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oai:recercat.cat:2445/675442025-11-19T10:50:03Zcom_2072_1057col_2072_478816col_2072_478917

Zebrafish as a model for developmental toxicity assessment Teixidó Condomines, Elisabet Piqué Benages, Maria Esther Boix Sabrià, Núria Llobet Mallafré, Joan M. (Joan Maria) Gómez Catalán, Jesús Peix zebra Toxicologia Zebra fish Toxicology Podeu consultar el llibre complet a: http://hdl.handle.net/2445/67430 The zebrafish embryo has emerged as promising alternative model for traditional in vivo developmental toxicological screening due to their advantageous characteristics as their small size and transparency. In this paper, we reviewed the applicability of the zebrafish embryo model in some relevant areas to human t oxicology as developmental toxicity, cardiovascular toxicity and neurotoxicity (behavioral assessment). Despite the promising results, further optimization and testing of more substances as well as a harmonized methodology is needed to streamline the metho ds and make the assay conducive to medium - throughput. 2015-10-29T18:27:38Z 2015-10-29T18:27:38Z 2015 info:eu-repo/semantics/bookPart info:eu-repo/semantics/publishedVersion Reproducció del capítol del llibre publicat a: http://www.trnres.com/ebookcontents.php?id=249 Recent Advances in Pharmaceutical Sciences V, 2015, Research Signpost. Editors: Diego Muñoz Torrero, M. Pilar Vinardell & Javier Palazón. ISBN: 978-81-308-0561-0. Chapter 5, p. 65-83. http://hdl.handle.net/2445/67430 (c) Research Signpost, 2015 info:eu-repo/semantics/openAccess Research Signpost Llibres / Capítols de llibre (Farmacologia, Toxicologia i Química Terapèutica)