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oai:recercat.cat:2445/661182025-11-19T11:04:39Zcom_2072_1057col_2072_478917col_2072_478924

(1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors Vázquez Fresno, Rosa Llorach, Rafael Alcaro, Francesca Rodríguez Martínez, Miguel Ángel Vinaixa Crevillent, Maria Chiva Blanch, Gemma Estruch Riba, Ramon Correig Blanchar, Xavier Andrés Lacueva, Ma. Cristina Vi Consum d'alcohol Metabolisme Malalties cardiovasculars Ressonància magnètica nuclear Marcadors bioquímics Metabòlits Wine Drinking of alcoholic beverages Metabolism Cardiovascular diseases Nuclear magnetic resonance Biochemical markers Metabolites Moderate wine consumption is associated with health-promoting activities. An H-NMR-based metabolomic approach was used to identify urinary metabolomic differences of moderate wine intake in the setting of a prospective, randomized, crossover, and controlled trial. Sixty-one male volunteers with high cardiovascular risk factors followed three dietary interventions (28 days): dealcoholized red wine (RWD) (272mL/day, polyphenol control), alcoholized red wine (RWA) (272mL/day) and gin (GIN) (100mL/day, alcohol control). After each period, 24-h urine samples were collected and analyzed by (1) H-NMR. According to the results of a one-way ANOVA, significant markers were grouped in four categories: alcohol-related markers (ethanol); gin-related markers; wine-related markers; and gut microbiota markers (hippurate and 4-hydroxphenylacetic acid). Wine metabolites were classified into two groups; first, metabolites of food metabolome: tartrate (RWA and RWD), ethanol, and mannitol (RWA); and second, biomarkers that relates to endogenous modifications after wine consumption, comprising branched-chain amino acid (BCAA) metabolite (3-methyl-oxovalerate). Additionally, a possible interaction between alcohol and gut-related biomarkers has been identified. To our knowledge, this is the first time that this approach has been applied in a nutritional intervention with red wine. The results show the capacity of this approach to obtain a comprehensive metabolome picture including food metabolome and endogenous biomarkers of moderate wine intake. 2015-06-29T17:01:28Z 2015-06-29T17:01:28Z 2012-08 2015-06-29T17:01:28Z info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Versió postprint del document publicat a: http://dx.doi.org/10.1002/elps.201100646 Electrophoresis, 2012, vol. 33, num. 15, p. 2345-2354 http://dx.doi.org/10.1002/elps.201100646 (c) Wiley-VCH, 2012 info:eu-repo/semantics/openAccess Wiley-VCH Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)