2026-04-17T15:56:11Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/661182025-11-19T11:04:39Zcom_2072_1057col_2072_478917col_2072_478924
RECERCAT
author
Vázquez Fresno, Rosa
author
Llorach, Rafael
author
Alcaro, Francesca
author
Rodríguez Martínez, Miguel Ángel
author
Vinaixa Crevillent, Maria
author
Chiva Blanch, Gemma
author
Estruch Riba, Ramon
author
Correig Blanchar, Xavier
author
Andrés Lacueva, Ma. Cristina
2015-06-29T17:01:28Z2015-06-29T17:01:28Z2012-082015-06-29T17:01:28Z
Moderate wine consumption is associated with health-promoting activities. An H-NMR-based metabolomic approach was used to identify urinary metabolomic differences of moderate wine intake in the setting of a prospective, randomized, crossover, and controlled trial. Sixty-one male volunteers with high cardiovascular risk factors followed three dietary interventions (28 days): dealcoholized red wine (RWD) (272mL/day, polyphenol control), alcoholized red wine (RWA) (272mL/day) and gin (GIN) (100mL/day, alcohol control). After each period, 24-h urine samples were collected and analyzed by (1) H-NMR. According to the results of a one-way ANOVA, significant markers were grouped in four categories: alcohol-related markers (ethanol); gin-related markers; wine-related markers; and gut microbiota markers (hippurate and 4-hydroxphenylacetic acid). Wine metabolites were classified into two groups; first, metabolites of food metabolome: tartrate (RWA and RWD), ethanol, and mannitol (RWA); and second, biomarkers that relates to endogenous modifications after wine consumption, comprising branched-chain amino acid (BCAA) metabolite (3-methyl-oxovalerate). Additionally, a possible interaction between alcohol and gut-related biomarkers has been identified. To our knowledge, this is the first time that this approach has been applied in a nutritional intervention with red wine. The results show the capacity of this approach to obtain a comprehensive metabolome picture including food metabolome and endogenous biomarkers of moderate wine intake.
(c) Wiley-VCH, 2012 info:eu-repo/semantics/openAccess
Vi
Consum d'alcohol
Metabolisme
Malalties cardiovasculars
Ressonància magnètica nuclear
Marcadors bioquímics
Metabòlits
Wine
Drinking of alcoholic beverages
Metabolism
Cardiovascular diseases
Nuclear magnetic resonance
Biochemical markers
Metabolites
(1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion