2026-04-17T20:34:06Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/661182025-11-19T11:04:39Zcom_2072_1057col_2072_478917col_2072_478924

00925njm 22002777a 4500 dc Vázquez Fresno, Rosa author Llorach, Rafael author Alcaro, Francesca author Rodríguez Martínez, Miguel Ángel author Vinaixa Crevillent, Maria author Chiva Blanch, Gemma author Estruch Riba, Ramon author Correig Blanchar, Xavier author Andrés Lacueva, Ma. Cristina author 2015-06-29T17:01:28Z 2015-06-29T17:01:28Z 2012-08 2015-06-29T17:01:28Z Moderate wine consumption is associated with health-promoting activities. An H-NMR-based metabolomic approach was used to identify urinary metabolomic differences of moderate wine intake in the setting of a prospective, randomized, crossover, and controlled trial. Sixty-one male volunteers with high cardiovascular risk factors followed three dietary interventions (28 days): dealcoholized red wine (RWD) (272mL/day, polyphenol control), alcoholized red wine (RWA) (272mL/day) and gin (GIN) (100mL/day, alcohol control). After each period, 24-h urine samples were collected and analyzed by (1) H-NMR. According to the results of a one-way ANOVA, significant markers were grouped in four categories: alcohol-related markers (ethanol); gin-related markers; wine-related markers; and gut microbiota markers (hippurate and 4-hydroxphenylacetic acid). Wine metabolites were classified into two groups; first, metabolites of food metabolome: tartrate (RWA and RWD), ethanol, and mannitol (RWA); and second, biomarkers that relates to endogenous modifications after wine consumption, comprising branched-chain amino acid (BCAA) metabolite (3-methyl-oxovalerate). Additionally, a possible interaction between alcohol and gut-related biomarkers has been identified. To our knowledge, this is the first time that this approach has been applied in a nutritional intervention with red wine. The results show the capacity of this approach to obtain a comprehensive metabolome picture including food metabolome and endogenous biomarkers of moderate wine intake. Vi Consum d'alcohol Metabolisme Malalties cardiovasculars Ressonància magnètica nuclear Marcadors bioquímics Metabòlits Wine Drinking of alcoholic beverages Metabolism Cardiovascular diseases Nuclear magnetic resonance Biochemical markers Metabolites (1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors