2026-04-03T20:25:15Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/648902025-12-04T21:12:13Zcom_2072_1057col_2072_478781col_2072_478917
RECERCAT
author
Franco Fernández, Rafael
author
Navarro Brugal, Gemma
author
Martínez-Pinilla, Eva
author
Moreno Guillén, Estefanía
2015-04-10T13:33:39Z2015-04-10T13:33:39Z2014-12-292015-04-10T13:33:40Z
The amyloid precursor protein (APP) is mainly known for being the precursor of the ß-amyloid peptide, which accumulates in plaques found in the brain of Alzheimer's disease patients. Expression in different tissues and the degree of sequence identity among mammals indicate an essential and non-tissue specific physiological function. APP is anchored to the membrane and displays a single C-terminal intracellular domain and a longer N-terminal extracellular domain. The basic biochemical properties and the scattered data on research, not related to production of beta-amyloid peptide, suggest that the protein and the molecules resulting from APP proteolytic cleavage may act as adhesion factors, enzymes, hormones/neurotransmitters and/or protease inhibitors. APP deserves to be known for its quite notable properties and its physiological role(s).
(c) Franco Fernández, Rafael et al., 2014 info:eu-repo/semantics/openAccess
Malaltia d'Alzheimer
Expressió gènica
Proteïnes de membrana
Alzheimer's disease
Gene expression
Membrane proteins
Amyloid Beta Precursor Protein: Proper Credit for the Basic Biochemical Properties of the Most Studied Protein in the 21st Century
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion