2026-04-17T16:19:44Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/644692025-11-20T13:54:02Zcom_2072_1057col_2072_478778col_2072_478917

00925njm 22002777a 4500 dc Aguilera, María del Carmen author Arias Sampériz, Bárbara author Wichers, Marieke author Barrantes Vidal, Neus author Moya Higueras, Jorge author Villa Martín, Helena author Os, J. van (Jim van) author Ibáñez Ribes, Manuel Ignacio author Ruipérez Rodríguez, María Ángeles author Ortet i Fabregat, Generós author Fañanás Saura, Lourdes author 2015-03-24T11:18:04Z 2015-03-24T11:18:04Z 2009-09 2015-03-24T11:18:04Z Background Adverse childhood experiences have been described as one of the major environmental risk factors for depressive disorder. Similarly, the deleterious impact of early traumatic experiences on depression seems to be moderated by individual genetic variability. Serotonin transporter (5-HTT) and brain-derived neurotrophic factor (BDNF) modulate the effect of childhood adversity on adult depression, although inconsistencies across studies have been found. Moreover, the gene×environment (G×E) interaction concerning the different types of childhood adversity remains poorly understood. The aim of this study was to analyse the putative interaction between the 5-HTT gene (5-HTTLPR polymorphism), the BDNF gene (Val66Met polymorphism) and childhood adversity in accounting for adult depressive symptoms. Method A sample of 534 healthy individuals filled in self-report questionnaires of depressive symptomatology [the Symptom Check List 90 Revised (SCL-90-R)] and different types of childhood adversities [the Childhood Trauma Questionnaire (CTQ)]. The 5-HTTLPR polymorphism (5-HTT gene) and the Val66Met polymorphism (BDNF gene) were genotyped in the whole sample. Results Total childhood adversity (β=0.27, p<0.001), childhood sexual abuse (CSA; β=0.17, p<0.001), childhood emotional abuse (β=0.27, p<0.001) and childhood emotional neglect (β=0.22, p<0.001) had an impact on adult depressive symptoms. CSA had a greater impact on depressive symptoms in Met allele carriers of the BDNF gene than in the Val/Val group (F=5.87, p<0.0001), and in S carriers of the 5-HTTLPR polymorphism (5-HTT gene) (F=5.80, p<0.0001). Conclusions Childhood adversity per se predicted higher levels of adult depressive symptoms. In addition, BDNF Val66Met and 5-HTTLPR polymorphisms seemed to moderate the effect of CSA on adult depressive symptoms. Depressió psíquica Gens Psicopatologia Serotonina Depressió psíquica en els infants Medi ambient Població Mental depression Genes Pathological psychology Serotonin Depression in children Environment Population Early adversity and 5-HTT-BDNF genes:  New evidences of Gene-Environment interactions on depressive symptoms in a general population