2026-04-13T07:26:58Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/580312025-12-05T14:52:48Zcom_2072_1057col_2072_478917col_2072_478924
RECERCAT author Urpí Sardà, Mireia author Casas Rodríguez, Rosa M. author Chiva Blanch, Gemma author Romero-Mamani, Edwin Saúl author Valderas Martínez, Palmira author Salas Salvadó, Jordi author Covas Planells, María Isabel author Toledo Atucha, Estefanía author Andrés Lacueva, Ma. Cristina author Llorach, Rafael author García Arellano, Ana author Bulló, Mònica author Ruiz-Gutiérrez, Valentina author Lamuela Raventós, Rosa Ma. author Estruch Riba, Ramon 2014-10-03T11:46:13Z2012-04-252014-10-03T11:46:13Zinfo:eu-repo/date/embargoEnd/2099-01-01 Adherence to aMediterranean diet (MD) is associated with a reduced risk of coronary heart disease. However, themolecular mechanisms involved are not fully understood. The aim of this studywas to compare the effects of 2MD with those of a lowfat- diet (LFD) on circulating inflammatory biomarkers related to atherogenesis. A total of 516 participants included in the PreventionwithMediterraneanDiet Studywere randomized into 3 intervention groups [MD supplementedwith virgin olive oil (MD-VOO); MD supplemented with mixed nuts (MD-Nuts); and LFD]. At baseline and after 1 y, participants completed FFQ and adherence to MD questionnaires, and plasma concentrations of inflammatory markers including intercellular adhesion molecule-1(ICAM-1), IL-6, and 2 TNF receptors (TNFR60 and TNFR80) were measured by ELISA. At 1 y, the MD groups had lower plasma concentrations of IL-6, TNFR60, and TNFR80 (P , 0.05), whereas ICAM-1, TNFR60, and TNFR80 concentrations increased in the LFD group (P , 0.002). Due to between-group differences, participants in the 2 MD groups had lower plasma concentrations of ICAM-1, IL-6, TNFR60, and TNFR80 compared to those in the LFD group (P # 0.028). When participants were categorized in tertiles of 1-y changes in the consumption of selected foods, those in the highest tertile of virgin olive oil (VOO) and vegetable consumption had a lower plasma TNFR60 concentration compared with those in tertile 1 (P,0.02).Moreover, the only changes in consumption thatwere associated with 1-y changes in the geometricmean TNFR60 concentrations were those of VOO and vegetables (P = 0.01). This study suggests that a MD reduces TNFR concentrations in patients at high cardiovascular risk. (c) American Society for Nutrition, 2012 info:eu-repo/semantics/embargoedAccess Malalties cardiovasculars Cuina mediterrània Suplements nutritius Inflamació Olis vegetals Fruita seca Cardiovascular diseases Mediterranean cooking Dietary supplements Inflammation Vegetable oils Dried fruit The mediterranean diet pattern and its main components are associated with lower plasma concentrations of tumor necrosis factor receptor 60 in patients at high risk for cardiovascular disease info:eu-repo/semantics/article