2026-04-17T15:45:59Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/580292025-11-21T05:33:54Zcom_2072_1057col_2072_478917col_2072_478921col_2072_478924
RECERCAT author Chiva Blanch, Gemma author Urpí Sardà, Mireia author Llorach, Rafael author Rotchés Ribalta, Maria author Guillén, Marisa author Casas Rodríguez, Rosa M. author Arranz Martínez, Sara author Valderas Martínez, Palmira author Portolés, Olga author Corella Piquer, Dolores author Tinahones, Francisco J. author Lamuela Raventós, Rosa Ma. author Andrés Lacueva, Ma. Cristina author Estruch Riba, Ramon 2014-10-03T11:25:00Z2011-12-282014-10-03T11:25:02Zinfo:eu-repo/date/embargoEnd/2099-01-01 Background: Few clinical studies have focused on the alcoholindependent cardiovascular effects of the phenolic compounds of red wine (RW). Objective: We aimed to evaluate the effects of ethanol and phenolic compounds of RW on the expression of inflammatory biomarkers related to atherosclerosis in subjects at high risk of cardiovascular disease. Design: Sixty-seven high-risk, male volunteers were included in a randomized, crossover consumption trial. After a washout period, all subjects received RW (30 g alcohol/d), the equivalent amount of dealcoholized red wine (DRW), or gin (30 g alcohol/d) for 4 wk. Before and after each intervention period, 7 cellular and 18 serum inflammatory biomarkers were evaluated. Results: Alcohol increased IL-10 and decreased macrophage-derived chemokine concentrations, whereas the phenolic compounds of RW decreased serum concentrations of intercellular adhesion molecule- 1, E-selectin, and IL-6 and inhibited the expression of lymphocyte function-associated antigen 1 in T lymphocytes and macrophage-1 receptor, Sialil-Lewis X, and C-C chemokine receptor type 2 expression in monocytes. Both ethanol and phenolic compounds of RW downregulated serum concentrations of CD40 antigen, CD40 ligand, IL-16, monocyte chemotactic protein-1, and vascular cell adhesion molecule-1. Conclusion: The results suggest that the phenolic content of RW may modulate leukocyte adhesion molecules, whereas both ethanol and polyphenols of RW may modulate soluble inflammatory mediators in high-risk patients. The trial was registered in the International Standard Randomized Controlled Trial Number Register at http://www. isrctn.org/ as ISRCTN88720134 (c) American Society for Nutrition, 2012 info:eu-repo/semantics/embargoedAccess Agents antiinflamatoris Vi Aterosclerosi Citoquines Polifenols Fitoteràpia Assaigs clínics Antiinflammatory agents Wine Atherosclerosis Cytokines Polyphenols Phytotherapy Clinical trials Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial info:eu-repo/semantics/article