2026-04-13T07:14:46Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/538502025-12-04T19:01:19Zcom_2072_1057col_2072_478777col_2072_478917

00925njm 22002777a 4500 dc Olloquequi, Jordi author Garcia Valero, Josep author Rodríguez, Esther author Montero, M. Angeles author Ferrer Sancho, Jaume, 1958- author Montes Castillo, Juan Francisco author 2014-05-05T13:58:54Z 2014-05-05T13:58:54Z 2012 2014-05-05T13:58:54Z Among all inflammatory cells involved in COPD, those with a cytolytic or elastolytic activity are thought to play a key role in the pathogenesis of the disease. However, there is no data about the infiltration of cells expressing the CD57 marker in small airways and parenchyma of COPD patients. In this study, surgical specimens from 43 subjects undergoing lung resection due to lung cancer (9 non-smokers, 18 smokers without COPD and 16 smokers with moderate COPD) and 16 patients undergoing double lung transplantation for very severe COPD were examined. CD57+ cells, neutrophils, macrophages and mast cells infiltrating bronchioles (epithelium, smooth muscle and connective tissue) and parenchymal interstitium were localized and quantified by immunohistochemical analysis. Compared to the other groups, the small airways of very severe COPD patients showed a significantly higher density of CD57+ cells, mainly infiltrated in the connective tissue (p=0.001), and a significantly higher density of neutrophils located characteristically in the epithelium (p=0.037). Also, the density of neutrophils was significantly higher in parenchyma of very severe COPD patients compared with the rest of the groups (p=0.001). Finally, there were significant correlations between the bronchiolar density of CD57+ cells and the FEV1 values (R=-0.43, p=0.022), as well as between the parenchymal density of neutrophils and macroscopic emphysema degree (R=0.43, p=0.048) in COPD groups. These results show that CD57+ cells may be involved in COPD pathogenesis, especially in the most severe stages of the disease. Malalties pulmonars obstructives cròniques Malalties del pulmó Càncer de pulmó Cèl·lules canceroses Chronic obstructive pulmonary diseases Pulmonary diseases Lung cancer Cancer cells Lung CD57+ cell density is increased in very severe COPD