2026-04-17T03:14:47Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/535282025-12-04T21:43:03Zcom_2072_1057col_2072_478917col_2072_478933

00925njm 22002777a 4500 dc Elduque Busquets, Xavier author Pedroso Muller, Enrique author Grandas Sagarra, Anna author 2014-04-22T09:55:44Z 2015-12-31T23:01:52Z 2014-03-11 2014-04-10T10:41:14Z Cyclic peptides and peptoids were prepared using the thiol-ene Michael-type reaction. The linear precursors were provided with additional functional groups allowing for subsequent conjugation: an orthogonally protected thiol, a protected maleimide, or an alkyne. The functional group for conjugation was placed either within the cycle or in an external position. The click reactions employed for conjugation with suitably derivatized nucleoside or oligonucleotides were either cycloadditions (Diels-Alder, Cu(I)-catalyzed azide-alkyne) or the same Michael-type reaction as for cyclization. Pèptids Àcids nucleics Ciclització (Química) Aminoàcids Proteïnes Peptides Nucleic acids Ring formation (Chemistry) Amino acids Proteins Orthogonal protection of peptides and peptoids for cyclization by the thiol-ene reaction and conjugation