2026-04-13T11:45:17Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/506702025-12-05T10:20:53Zcom_2072_1057col_2072_478917col_2072_478927
RECERCAT author Chimenos Küstner, Eduardo author Pascual Cruz, Montserrat author Piñol Dansis, Cristina author Viñals Iglesias, Helena author Rodríguez de Rivera Campillo, Ma Eugenia author López López, José, 1958- 2014-02-27T10:10:17Z2014-02-27T10:10:17Z2006-11-012014-02-27T10:10:17Z Podeu consultar la versió en castellà a http://hdl.handle.net/2445/117327Leprosy is a contagious and chronic systemic granulomatous disease caused by Mycobacterium leprae (Hansen"s bacillus). It is transmitted from person to person and has a long incubation period (between two and six years). The disease presents polar clinical forms (the"multibacillary" lepromatous leprosy and the"paucibacillary" tuberculoid leprosy), as well as other intermediate forms with hybrid characteristics. Oral manifestations usually appear in lepromatous leprosy and occur in 20-60% of cases. They may take the form of multiple nodules (lepromas) that progress to necrosis and ulceration. The ulcers are slow to heal, and produce atrophic scarring or even tissue destruction. The lesions are usually located on the hard and soft palate, in the uvula, on the underside of the tongue, and on the lips and gums. There may also be destruction of the anterior maxilla and loss of teeth. The diagnosis, based on clinical suspicion, is confirmed through bacteriological and histopathological analyses, as well as by means of the lepromin test (intradermal reaction that is usually negative in lepromatous leprosy form and positive in the tuberculoid form). The differential diagnosis includes systemic lupus erythematosus, sarcoidosis, cutaneous leishmaniasis and other skin diseases, tertiary syphilis, lymphomas, systemic mycosis, traumatic lesions and malignant neoplasias, among other disorders. Treatment is difficult as it must be continued for long periods, requires several drugs with adverse effects and proves very expensive, particularly for less developed countries. The most commonly used drugs are dapsone, rifampicin and clofazimine. Quinolones, such as ofloxacin and pefloxacin, as well as some macrolides, such as clarithromycin and minocyclin, are also effective. The present case report describes a patient with lepromatous leprosy acquired within a contagious family setting during childhood and adolescence (c) Medicina Oral SL, 2006 info:eu-repo/semantics/openAccess Lepra Diagnòstic diferencial Malalties infeccioses Malalties de la boca Leprosy Differential diagnosis Communicable diseases Mouth diseases Lepromatous leprosy: a review and case report info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion