2026-04-13T02:01:47Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/494792025-12-04T21:44:12Zcom_2072_1057col_2072_478917col_2072_478933
RECERCAT
author
Elduque Busquets, Xavier
author
Pedroso Muller, Enrique
author
Grandas Sagarra, Anna
2014-02-06T14:05:30Z2014-12-31T23:02:05Z20132014-02-06T11:49:36Z
Cyclic peptide architectures can be easily synthesized from cysteine-containing peptides with appending maleimides, free or protected, through an intramolecular Michael-type reaction. After peptide assembly, the peptide can cyclize either during the trifluoroacetic acid treatment, if the maleimide is not protected, or upon deprotection of the maleimide. The combination of free and protected maleimide moieties and two orthogonally protected cysteines gives access to structurally different bicyclic peptides with isolated or fused cycles.
(c) American Chemical Society , 2013 info:eu-repo/semantics/openAccess
Aminoàcids
Pèptids
Proteïnes
Amino acids
Peptides
Proteins
Straightforward synthesis of cyclic and bicyclic peptides
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion