2026-04-13T04:49:43Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/494792025-12-04T21:44:12Zcom_2072_1057col_2072_478917col_2072_478933

00925njm 22002777a 4500 dc Elduque Busquets, Xavier author Pedroso Muller, Enrique author Grandas Sagarra, Anna author 2014-02-06T14:05:30Z 2014-12-31T23:02:05Z 2013 2014-02-06T11:49:36Z Cyclic peptide architectures can be easily synthesized from cysteine-containing peptides with appending maleimides, free or protected, through an intramolecular Michael-type reaction. After peptide assembly, the peptide can cyclize either during the trifluoroacetic acid treatment, if the maleimide is not protected, or upon deprotection of the maleimide. The combination of free and protected maleimide moieties and two orthogonally protected cysteines gives access to structurally different bicyclic peptides with isolated or fused cycles. Aminoàcids Pèptids Proteïnes Amino acids Peptides Proteins Straightforward synthesis of cyclic and bicyclic peptides