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oai:recercat.cat:2445/494792025-12-04T21:44:12Zcom_2072_1057col_2072_478917col_2072_478933

urn:hdl:2445/49479 Straightforward synthesis of cyclic and bicyclic peptides Elduque Busquets, Xavier Pedroso Muller, Enrique Grandas Sagarra, Anna Aminoàcids Pèptids Proteïnes Amino acids Peptides Proteins Cyclic peptide architectures can be easily synthesized from cysteine-containing peptides with appending maleimides, free or protected, through an intramolecular Michael-type reaction. After peptide assembly, the peptide can cyclize either during the trifluoroacetic acid treatment, if the maleimide is not protected, or upon deprotection of the maleimide. The combination of free and protected maleimide moieties and two orthogonally protected cysteines gives access to structurally different bicyclic peptides with isolated or fused cycles. 2014-02-06T14:05:30Z 2014-12-31T23:02:05Z 2013 2014-02-06T11:49:36Z info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Versió postprint del document publicat a: http://dx.doi.org/10.1021/ol400726y Organic Letters, 2013, vol. 15, num. 8, p. 2038-2041 http://dx.doi.org/10.1021/ol400726y (c) American Chemical Society , 2013 info:eu-repo/semantics/openAccess American Chemical Society Articles publicats en revistes (Química Inorgànica i Orgànica)