2026-04-13T15:10:48Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/494232025-12-04T21:42:46Zcom_2072_1057col_2072_478917col_2072_478933

00925njm 22002777a 4500 dc Elduque Busquets, Xavier author Sánchez-Moya, Albert author Sharma, Kapil author Pedroso Muller, Enrique author Grandas Sagarra, Anna author 2014-02-05T09:00:14Z 2014-12-31T23:02:05Z 2013 2014-02-04T15:10:00Z Monomers allowing for the introduction of [2,5-dimethylfuran]-protected maleimides into polyamides such as peptides, peptide nucleic acids, and peptoids were prepared, as well as the corresponding oligomers. Suitable maleimide deprotection conditions were established in each case. The stability of the adducts generated by Michael-type maleimide-thiol reaction and Diels-Alder cycloaddition to maleimide deprotection conditions was exploited to prepare a variety of conjugates from peptide and PNA scaffolds incorporating one free and one protected maleimide. The target molecules were synthesized by using two subsequent maleimide-involving click reactions separated by a maleimide deprotection step. Carrying out maleimide deprotection and conjugation simultaneously gave better results than performing the two reactions subsequently. Pèptids Àcids nucleics Oligòmers Síntesi orgànica Biotecnologia Aminoàcids Proteïnes Peptides Nucleic acids Oligomers Organic synthesis Biotechnology Amino acids Proteins Protected maleimide building blocks for the decoration of peptides, peptoids and peptide nucleic acids