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Task-induced deactivation from rest extends beyond the default mode brain network Harrison, Ben J. Pujol Nuez, Jesús Contreras Rodríguez, Oren Soriano Mas, Carles López-Solà, Marina Deus Yela, Juan Ortiz, Hector Blanco Hinojo, Laura, 1981- Alonso Ortega, María del Pino Hernández Ribas, Rosa Cardoner, N. (Narcís) Menchón Magriñá, José Manuel Cognició Mapatge del cervell Assaigs clínics Cognition Brain mapping Clinical trials Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized"default-mode network" (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes. 2013-06-06T14:10:13Z 2013-06-06T14:10:13Z 2011 2013-06-06T14:10:13Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: 10.1371/journal.pone.0022964 PLoS One, 2011, vol. 6, num. 7, p. e22964 http://dx.doi.org/10.1371/journal.pone.0022964 cc-by (c) Harrison, Ben J. et al., 2011 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess Public Library of Science (PLoS) Articles publicats en revistes (Ciències Clíniques)