2026-04-17T03:03:21Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/440922025-12-05T13:11:51Zcom_2072_1057col_2072_478798col_2072_478916col_2072_478917
RECERCAT author Harrison, Ben J. author Pujol Nuez, Jesús author Contreras Rodríguez, Oren author Soriano Mas, Carles author López-Solà, Marina author Deus Yela, Juan author Ortiz, Hector author Blanco Hinojo, Laura, 1981- author Alonso Ortega, María del Pino author Hernández Ribas, Rosa author Cardoner, N. (Narcís) author Menchón Magriñá, José Manuel 2013-06-06T14:10:13Z2013-06-06T14:10:13Z20112013-06-06T14:10:13Z Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized"default-mode network" (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes. cc-by (c) Harrison, Ben J. et al., 2011 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess Cognició Mapatge del cervell Assaigs clínics Cognition Brain mapping Clinical trials Task-induced deactivation from rest extends beyond the default mode brain network info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion