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Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics García Garcerà, M. Gigli, E. Sánchez Quinto, Federico Ramírez, Oscar Calafell, Francesc Civit Vives, Sergi Lalueza Fox, Carles, 1965- ADN fòssil ADN Paleobiologia Fossil DNA DNA Paleobiology Despite the successful retrieval of genomes from past remains, the prospects for human palaeogenomics remain unclear because of the difficulty of distinguishing contaminant from endogenous DNA sequences. Previous sequence data generated on high-throughput sequencing platforms indicate that fragmentation of ancient DNA sequences is a characteristic trait primarily arising due to depurination processes that create abasic sites leading to DNA breaks. 2013-05-17T14:44:30Z 2013-05-17T14:44:30Z 2011 2013-05-17T14:44:30Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0024161 PLoS One, 2011, vol. 6, num. 8, p. e24161 http://dx.doi.org/10.1371/journal.pone.0024161 cc-by (c) García Garcerà, M. et al., 2011 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess Public Library of Science (PLoS) Articles publicats en revistes (Genètica, Microbiologia i Estadística)