2026-04-14T03:36:33Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/345262025-12-05T09:21:48Zcom_2072_1057col_2072_478799col_2072_478916col_2072_478917

Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model Kurdián, Melania Herrero Fresneda, Immaculada Lloberas Blanch, Núria Giménez Bonafé, Pepita Coria, Virginia Grande, María T. Boggia, José Malacrida, Leonel Torras Ambròs, Joan Arévalo, Miguel A. González-Martínez, Francisco López-Novoa, José M. Grinyó Boira, Josep M. Noboa, Oscar Medicaments Transplantament renal Proteïnúria Immunosupressió Drugs Kidney transplantation Proteinuria Immunosuppression The immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating cell growth, proliferation, differentiation, migration, and survival. The aim of this study was to analyze the effects of delayed inhibition of mTOR pathway with low dose of everolimus on progression of renal disease and TGFβ expression in the 5/6 nephrectomy model in Wistar rats. 2013-04-11T11:31:24Z 2013-04-11T11:31:24Z 2012-03-12 2013-04-11T11:31:24Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1932-6203 https://hdl.handle.net/2445/34526 606624 22427849 eng Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0032516 PLoS One, 2012, vol. 7, núm. 3, p. e32516 http://dx.doi.org/10.1371/journal.pone.0032516 cc-by (c) Kurdián et al., 2012 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess 9 p. application/pdf Public Library of Science (PLoS) Articles publicats en revistes (Ciències Fisiològiques)