2026-04-17T06:12:19Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/345262025-12-05T09:21:48Zcom_2072_1057col_2072_478799col_2072_478916col_2072_478917
RECERCAT
author
Kurdián, Melania
author
Herrero Fresneda, Immaculada
author
Lloberas Blanch, Núria
author
Giménez Bonafé, Pepita
author
Coria, Virginia
author
Grande, María T.
author
Boggia, José
author
Malacrida, Leonel
author
Torras Ambròs, Joan
author
Arévalo, Miguel A.
author
González-Martínez, Francisco
author
López-Novoa, José M.
author
Grinyó Boira, Josep M.
author
Noboa, Oscar
2013-04-11T11:31:24Z2013-04-11T11:31:24Z2012-03-122013-04-11T11:31:24Z
The immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating cell growth, proliferation, differentiation, migration, and survival. The aim of this study was to analyze the effects of delayed inhibition of mTOR pathway with low dose of everolimus on progression of renal disease and TGFβ expression in the 5/6 nephrectomy model in Wistar rats.
cc-by (c) Kurdián et al., 2012 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
Medicaments
Transplantament renal
Proteïnúria
Immunosupressió
Drugs
Kidney transplantation
Proteinuria
Immunosuppression
Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion