2026-04-17T06:05:01Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/279332025-11-19T20:41:42Zcom_2072_1057col_2072_478781col_2072_478917

00925njm 22002777a 4500 dc González, Sergio author Moreno-Delgado, David author Moreno Guillén, Estefanía author Pérez Capote, Kamil author Franco Fernández, Rafael author Mallol Montero, Josefa author Cortés Tejedor, Antonio author Casadó, Vicent author Lluís i Biset, Carme author Ortiz, Jordi author Ferré, Sergi author Canela Campos, Enric I. (Enric Isidre), 1949- author McCormick, Peter J. author 2012-06-28T09:13:08Z 2012-06-28T09:13:08Z 2012-06-19 2012-06-28T09:13:09Z The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals that are transmitted to the rest of the neuronal system in the form of serotonin and melatonin synthesis and release. Here we describe that the production of both melatonin and serotonin by the pineal gland is regulated by a circadian-related heteromerization of adrenergic and dopamine D4 receptors. Through alpha18-D4 and ß1-D4 receptor heteromers dopamine inhibits adrenergic receptor signaling and blocks the synthesis of melatonin induced by adrenergic receptor ligands. This inhibition was not observed at hours of the day when D4 was not expressed. These data provide a new perspective on dopamine function and constitute the first example of a circadian-controlled receptor heteromer. The unanticipated heteromerization between adrenergic and dopamine D4 receptors provides a feedback mechanism for the neuronal hormone system in the form of dopamine to control circadian inputs. Glàndula pineal Melatonina Receptors adrenèrgics Adenosina Pineal gland Melatonin Adrenaline receptors Adenosine Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland